Increases in cholesterol levels need discussion too. We do see temporary increases in cholesterol levels often as individuals transition onto a ketogenic diet. However, when you examine lipid particle size (a more important way to look at the cardiovascular risks), the risk pattern doesn’t seem to increase with a ketogenic diet. Harvard Health has written about lipid particle size here before: http://www.health.harvard.edu/womens-health/should-you-seek-advanced-cholesterol-testing-
IF: So I thought I would try IF 16:8 this month. I just don't think this is for me at this time. The 3rd day, by the time it was time to eat, I was on the edge of a binge trigger. I could feel it bubbling up. With my past eating disorders, restriction like that becomes a trigger. I'm just not at a place yet where I feel confident in myself to do it.
Some athletes swear by the ketogenic diet, not just for weight loss but for improved performance in their sport, as well. But Edward Weiss, PhD, associate professor of nutrition and dietetics at Saint Louis University, doesn’t buy it. “I hear cyclists say all the time that they’re faster and better now that they’re on keto, and my first question is, 'Well, how much weight did you lose?'” he says.
How did this diet, which was first developed in the 1920s as a treatment for children with epilepsy (and has been shown to reduce seizures in patients whose epilepsy symptoms aren’t responding to other medications), become the diet du jour, and why such a discrepancy between its fandom and expert opinion? Let’s take a closer look at what “going keto” entails.
These types of back-and-forth weight fluctuations can contribute to disordered eating, Kizer says, or can worsen an already unhealthy relationship with food. “I think this diet appeals to people who have issues with portion control and with binge eating,” she says. "And in many cases, what they really need is a lifestyle coach or a professional counselor to help them get to the bottom of those issues."
Remember: Just because something fits your macros doesn’t mean it’s super healthful and providing a balance of nutrients. High consumption of certain foods (like hot dogs, bacon, and other processed meats) and under consumption of healthier foods (nuts, seeds, vegetables, fruit, whole grains) are linked with certain health conditions and death from heart disease, stroke, and type 2 diabetes, and that’s important to keep in mind even if we don’t necessarily have a causal link or recommended limit.
The ketone bodies are possibly anticonvulsant; in animal models, acetoacetate and acetone protect against seizures. The ketogenic diet results in adaptive changes to brain energy metabolism that increase the energy reserves; ketone bodies are a more efficient fuel than glucose, and the number of mitochondria is increased. This may help the neurons to remain stable in the face of increased energy demand during a seizure, and may confer a neuroprotective effect.
All in all, the biggest takeaway I got from trying the keto diet for a month (other than losing 11 pounds and 3 percent body fat) is this: Life is hard enough, so if you decide to go on a "diet" or drastically change your eating patterns, don't make it harder on yourself. That's a surefire way to fall off the wagon or give up. If you're hell-bent on trying keto but meticulous meal planning isn't your thing, that doesn't mean it isn't going to work for you—just that you need a little help. If that comes in the form of meal kits, so be it.
Early studies reported high success rates: in one study in 1925, 60% of patients became seizure-free, and another 35% of patients had a 50% reduction in seizure frequency. These studies generally examined a cohort of patients recently treated by the physician (what is known as a retrospective study) and selected patients who had successfully maintained the dietary restrictions. However, these studies are difficult to compare to modern trials. One reason is that these older trials suffered from selection bias, as they excluded patients who were unable to start or maintain the diet and thereby selected from patients who would generate better results. In an attempt to control for this bias, modern study design prefers a prospective cohort (the patients in the study are chosen before therapy begins) in which the results are presented for all patients regardless of whether they started or completed the treatment (known as intent-to-treat analysis).