The nerve impulse is characterised by a great influx of sodium ions through channels in the neuron's cell membrane followed by an efflux of potassium ions through other channels. The neuron is unable to fire again for a short time (known as the refractory period), which is mediated by another potassium channel. The flow through these ion channels is governed by a "gate" which is opened by either a voltage change or a chemical messenger known as a ligand (such as a neurotransmitter). These channels are another target for anticonvulsant drugs.[7]

“The cleaner, the better when it comes to the keto diet,” says Jadin. Focus on “whole” and “unprocessed.” Also, strive for a mix of saturated and unsaturated fats for balance. Note: Tipping the scale toward too much protein is a common pitfall many people make on the keto diet. Mind your protein intake, since too much can kick you out of ketosis, says Jadin.
Many ketogenic dieters also swear by MCT oil. (MCT simply stands for medium chain triglycerides.) MCT's energy-sustaining powers can be explained as follows: When MCT oil is metabolized in the body, it behaves more like a carbohydrate than a fat. Unlike other fats, MCT oil does not go through the lymphatic system. Instead, it is transported directly to the liver where it is metabolized so it releases energy like a carbohydrate and creates lots of ketones (which can be used for fuel) in the process.
One of my co workers who eats fast food everyday for breakfast and frozen meals for lunch tired to warn me about how my bacon and cabbage is going to cause me gout, because last week her husband bought regular beacon instead of turkey bacon and now she has gout ?!?! I just said wow gout is tough, careful those frozen meals might flare it up She has seen me drop from 292 to 215 since January eating veggies and meat, while she literally eats processed crap 2 meals each day The hate is real people

A ketogenic diet helps control blood sugar levels. It is excellent for managing type 2 diabetes, sometimes even leading to complete reversal of the disease. This has been proven in studies. It makes perfect sense since keto lowers blood-sugar levels, reduces the need of medications and reduces the potentially negative impact of high insulin levels.


H. Guldbrand, B. Dizdar, B. Bunjaku, T. Lindström, M. Bachrach-Lindström, M. Fredrikson, C. J. Östgren, F. H. Nystrom, “In Type 2 Diabetes, Randomisation to Advice to Follow a Low-carbohydrate Diet Transiently Improves Glycaemic Control Compared with Advice to Follow a Low-fat Diet Producing a Similar Weight Loss,” Diabetologia (2012) 55: 2118. http://link.springer.com/article/10.1007/s00125-012-2567-4.
The popular low-carb diets (such as Atkins or Paleo) modify a true keto diet. But they come with the same risks if you overdo it on fats and proteins and lay off the carbs. So why do people follow the diets? "They're everywhere, and people hear anecdotally that they work," McManus says. Theories about short-term low-carb diet success include lower appetite because fat burns slower than carbs. "But again, we don't know about the long term," she says. "And eating a restrictive diet, no matter what the plan, is difficult to sustain. Once you resume a normal diet, the weight will likely return."

And good news for coffee addicts: you can still have your morning cup of joe. You’ll just need to adjust what you stir into it. Switch out flavored creamer for the real deal—full-fat heavy whipping cream, which has only 1 gram of carbs per tablespoon. If you want to give your java a jolt of sweet, stir in a low-carb sweetener that uses sugar alcohols. But if you can skip the sweet, even better. In time, you’ll retrain your palate to not crave a sugary start to the day.
You’re transitioning. Your body is equipped to process a high intake of carbs and a lower intake of fat. Your body needs to create enzymes to be able to do this. In the transitional period, the brain may run low on energy which can lead to grogginess, nausea, and headaches. If you’re having a large problem with this, you can choose to reduce carb intake gradually.
Case in point: When I didn't have time to whip up a homemade keto snack—or even when I needed a keto-friendly dessert for my book club—I turned to Nui cookies. Not only did it satisfy my craving for a freaking cookie (the snickerdoodle and double chocolate flavors were my favorites), but they also use monk fruit extract, a sweetener that's reportedly 150 to 200 times sweeter than sugar (less is more!), so I didn't have to worry about going into carb overload from one cookie. In fact, I could have two. (Related: The Best Healthy Keto Packaged Snacks You Can Buy)
Protein will induce an insulin response in the body, if consumed in high amounts. The most intuitive way to start a keto diet for most people is by removing all of the carbs they have been eating. Typically people will replace those calories by increasing their lean meat consumption. That's a recipe for disaster! Keeping protein moderate is an often overlooked, but very important part of a keto diet. Most people need around 0.6g to 1.0g of protein per pound of lean body mass.
Aude, Y., A. S, Agatston, F. Lopez-Jimenez, et al. “The National Cholesterol Education Program Diet vs a Diet Lower in Carbohydrates and Higher in Protein and Monounsaturated Fat: A Randomized Trial.” JAMA Internal Medicine 164, no. 19 (2004): 2141–46. doi: 10.1001/archinte.164.19.2141. jamanetwork.com/journals/jamainternalmedicine/article-abstract/217514.
“Brain fog” is a common complaint among people on extremely low-carb diets like keto. “I remember one client in particular who had been put on a keto diet for her PCOS [polycystic ovary syndrome] who kept telling me how much better she felt after eating in a more balanced, more nourishing way for a couple of weeks at our program,” Notte says. Make sure you know these 15 things before starting the keto diet.
You can have a completely smooth transition into ketosis, or…not. While your body is adapting to using ketones as your new fuel source, you may experience a range of uncomfortable short-term symptoms. These symptoms are referred to as “the keto flu.” Low-sodium levels are often to blame for symptoms keto flu, since the kidneys secrete more sodium when you’re in ketosis, says Volek. A few side effects:
Some research suggests that ketogenic diets might help lower your risk of heart disease. Other studies show specific very-low-carb diets help people with metabolic syndrome, insulin resistance, and type 2 diabetes. Researchers are also studying the effects of these diets on acne, cancer, polycystic ovary syndrome (PCOS), and nervous system diseases like Alzheimer's, Parkinson's, and Lou Gehrig's disease.
Leftovers will be another thing we will take into consideration. Not only is it easier on you, but why put yourself through the hassle to cook the same food more than once? Breakfast is something I normally do leftover style, where I don’t have to worry about it in the morning and I certainly don’t have to stress about it. Grab some food out the fridge, pre-made for me, and head out the door. It doesn’t get much easier than that, does it?
As for how it feels to follow the diet, St. Pierre says it will vary from person to person; as with most diet-related things, whether or not a way of eating works is in the eye of the beholder. He’s seen some people feel fine, but that “some clients have found it causes brain fog and lethargy, decreases their performance, disrupts their regular bowel movements, and makes them feel generally crappy,” he says. Some keto adherents also report having pretty atrocious breath, which might be caused by the presence of acetone, a ketone and byproduct of fat metabolism, in exhaled breath.
A modified version of the ketogenic diet, which allows you to eat protein more liberally — at 20 to 30 percent of your total calories — with the same carbohydrate restriction, is the more commonly used version of the diet today. Some of the aims of the latest version of the ketogenic diet are weight loss, weight management, and improved athletic performance.
The American Heart Association’s recommendations for controlling cholesterol include getting more fiber and limiting your intake of saturated fat, both of which would be extremely difficult on a ketogenic diet. While it’s true that research around saturated fat is still evolving, making room for good sources of fiber and unsaturated fats, which reduce the risk of cardiovascular disease, and allowing for a more balanced intake of nutrients, is ideal. In any case, you should check with your doctor before you start a ketogenic (or any new) diet, especially if you have any health conditions like high blood pressure or high cholesterol.
I have great respect for Harvard Medical School. I notice that they support their readers posting comments and I am most appreciative of the article and all the many thoughtful comments by the readers. The readers seem to have the most expertise here and I hope that the doctor who wrote the article will think long and hard about the comments by readers. After 35 years of clinical practice in mental health, I notice that all issues of emotion involve medical issues, nutrition, and the gut bacteria. I would say that these issues and all of the executive brain functions seem to improve with ketogenic principles. For those that apply it in a flexible and smart manner, it appears to improve every area of their lives. I strongly encourage the author of the article to take one class via The Institute for Functional Medicine. If he is open to more learning he can take more classes and get certified. I’m sure a fine doctor, he will be an even better doctor and personally healthier, if he gets more training. Are we all open to new learning(especially us healthcare providers)?
Bonnie J. Brehm, Randy J. Seeley, Stephen R. Daniels, and David A. D’Alessio, “A Randomized Trial Comparing a Very Low Carbohydrate Diet and a Calorie-Restricted Low Fat Diet on Body Weight and Cardiovascular Risk Factors in Healthy Women,” The Journal of Clinical Endocrinology & Metabolism: Vol 88, No 4; January 14, 2009. http://press.endocrine.org/doi/full/10.1210/jc.2002-021480.
When some people attempt a ketogenic diet, they experience the “keto flu” during the period of time their bodies are adapting to the diet. This is a period of feeling lightheaded, lethargic, irritable, and unmotivated. “It typically lasts one to three days, and may very well be just the result of dehydration. A drop in insulin can impact renal sodium retention such that sodium and fluids are excreted more readily. This also acts to lower blood pressure,” Goss says.

Like most diets, the ketogenic diet is not a one-size-fits-all answer to all of our health and weight hopes and dreams. It might be enjoyable for some people, especially in the short term, but that doesn't mean it will be a fit for everyone. The experts we talked to for this post agreed that although it may lead to short term (water) weight loss, it might not be optimal as a sustainable weight loss solution. St. Pierre explains the way he sums it up for his clients: “I let them know that there isn't a universal approach that works for everyone, and that restrictive diets like keto can be hard for folks to stick to long-term.”
Before starting, ask yourself what is really realistic for you, Mattinson suggests. Then get your doctor’s okay. You may also work with a local registered dietitian nutritionist to limit potential nutrient deficiencies and talk about vitamin supplementation, as you won’t be eating whole grains, dairy, or fruit, and will eliminate many veggies. “A diet that eliminates entire food groups is a red flag to me. This isn’t something to take lightly or dive into headfirst with no medical supervision,” she says.
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